We are questioned the most about these products. This list is not comprehensive and was updated 1/27/2025.
*JVC does not recommend the use of topicals during lactation
Bold items are carried on the shelf at Janssen Veterinary Clinic. These and others are also available at store.jvc.vet
Green items are safe for all stages of breeding dogs.
Name
Use
Age/Weight
Administration
Safety for Breeding Dogs
Advantage Multi
Heartworm Fleas
Intestinal Parasites
(hook, round, whip)
>7 weeks
>3 lb
Topical*
Not tested
Advantus
Flea (Treatment)
>10 weeks
>4 lb
Oral
Not tested
Bravecto Chews
(12 week)
Flea
Tick
>6 months
>4.4 lb
Oral
SAFE
Capstar
Flea (Treatment)
>4 weeks
>2 lb
Oral
Labeled as SAFE, birth defects have been reported
Comfortis
Fleas
>14 weeks
>5 lb
Oral
Females: Caution
Males: Not tested
Credelio
Flea
Ticks
>8 weeks
>4.4 lb
Oral
Not tested
Frontline Plus
Flea
Ticks
>8 weeks
>5 lb
Topical*
SAFE
Frontline Shield
Flea
Ticks
Mosquitos
>9 weeks
>5 lb
Topical*
Not tested
Heartgard Plus
Heartworm
Intestinal Parasites
(hook, round)
>6 weeks
Oral
SAFE
Interceptor (NOT plus)
Heartworm
Intestinal Parasites
(hook, round, whip)
>4 weeks
>2 lb
Oral
SAFE
Interceptor Plus
Heartworm
Intestinal Parasites
(hook, round, whip, tape)
>6 weeks
>2 lb
Oral
Not tested
Iverhart Max
Heartworm
Intestinal
Parasites
(hook, round, tape)
>6 weeks
Oral
Females: Not tested
Males: SAFE
Iverhart Plus
Heartworm
Intestinal Parasites
(hook, round)
>6 weeks
Oral
SAFE
K9 Advantix (NOT Advantix II)
Flea
Ticks
Mosquitos
>7 weeks
>4 lb
Topical*
SAFE
K9 Advantix II
Flea
Ticks
Mosquitos
>7 weeks
>4 lb
Topical*
Not tested
Nexgard
Flea
Ticks
>8 weeks
>4 lb
Oral
Not tested
Nexgard Plus
Heartworm
Fleas
Ticks
Intestinal Parasites
>8 weeks
>4 lb
Oral
Not tested
Proheart 12
Heartworm
>12 months
>5 lb
Injectable
SAFE
Proheart 6
Heartworm
>6 months
>5 lb
Injectable
SAFE
Revolution
Heartworm
Fleas
Ticks
Mites (ear, sarcoptic mange)
>6 weeks
Topical*
SAFE
Sentinel Flavor Tabs
Heartworm
Fleas
Intestinal Parasites
(hook, round, whip)
>4 weeks
>2 lb
Oral
SAFE
Sentinel Spectrum
Heartworm
Fleas
Intestinal Parasites
(hook, round, whip, tape)
>6 weeks
>2 lb
Oral
Not tested
Seresto
Fleas
Ticks
>7 weeks
Collar
Not tested
Simparica
Fleas
Ticks
>6 months
>2.8 lb
Oral
Not tested (may be approved soon)
Simparica Trio
Heartworm
Fleas
Ticks
Intestinal Parasites
(hook, round)
>8 weeks
>2.8 lb
Oral
Not tested (may be approved soon)
Trifexis
Heartworm
Fleas
Intestinal Parasites
(hook, round, whip)
>8 weeks
>5 lb
Oral
Females: Caution
Males: Not tested
Tri-Heart Plus
Heartworm
Intestinal Parasites
(hook, round)
>6 weeks
Oral
SAFE
Vectra 3D
Flea
Ticks
Mosquitos
>8 weeks
>11 lb
Topical*
DO NOT USE